KEGG   REACTION: R06459
Entry
R06459                      Reaction                               
Name
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide forming)
Definition
6 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> Narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
Equation
6 C00683 + C00083 + 5 C00005 + 5 C00080 <=> C11997 + 7 C00010 + 7 C00011 + 5 C00006 + 2 C00001
Comment
type I polyketide synthase, PikA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00683
RC02828  C00683_C11997
RC02829  C00683_C11997
RC02830  C00683_C11997
RC02910  C00683_C11997
RC02911  C00083_C11997
RC02915  C00683_C11997
RC03330  C00683_C11997
Enzyme
2.3.1.240
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.240
     R06459  6 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> Narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
Orthology
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
Other DBs
RHEA: 42847

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG RCLASS (9)   
Gene (8)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (4)   
All databases (35)   

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